Faculty Information - Ookuri Takatoshi | SOJO UNIVERSITY

（Last updated : 2024-04-08 08:47:01）

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Ookuri Takatoshi

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2024/03	Papers	Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochem Biophys Res Commun. 12 (700),pp.149592 (Co-authored)
2.	2023/12	Papers	Enhancing thermal stability in the CH2 domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris. Protein Science 32 (12),pp.e4831 (Co-authored)
3.	2023/09	Papers	Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab. The Journal of Biochemistry 174 (4),pp.345-353 (Co-authored)
4.	2022/06	Papers	Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity. The Journal of Biochemistry 172 (1),pp.49-56 (Co-authored)
5.	2021/10	Papers	High-level expression of human CH2 domain from the Fc region in Pichia pastoris and preparation of anti-CH2 antibodies. The Journal of Biochemistry 170 (2),pp.289-297 (Co-authored)
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Academic conference presentation
1.	2019/09/20	Introduction of a glycosylation site in the constant region of human Fab and effect of the effect of glycosylation on the properties of the Fab
2.	2019/06/25	Preparation of C-terminal specific PEG modified Fab with intermolecular disulfide bond

Academic background
1.	1990/04～1994/03	Faculty of Pharmaceutical Science Fukuoka University Graduated
2.	1994/04～1996/03	Master Graduate School, Division of Pharmaceutical Sciences Kyushu University Finished
3.	1996/04～1999/03	Doctorial Graduate School, Division of Pharmaceutical Sciences Kyushu University Finished (Physical pharmacy)

Business career
1.	2002/04 ～ 2008/03	Research Assistant
2.	2008/04 ～ 2009/09	Assistant Professor
3.	2009/10/01 ～ 2020/03/31	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
4.	2012/04/01 ～	/(DC)Division of Pharmaceutical Sciences

E-Mail Address

Present specialized field
Pharmaceutical analytical chemistry and physicochemistry, Immunology, Pharmaceutical analytical chemistry and physicochemistry

Department laboratory expense researcher number
70346807