Faculty Information - Shuto Keiko | SOJO UNIVERSITY

（Last updated : 2025-08-25 15:29:09）

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Shuto Keiko

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2022/07	Papers	A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells. International Journal of Molecular Sciences 23 (14),pp.7748 (Co-authored)
2.	2022/03	Papers	Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases. Journal of Pharmacological Sciences 149 (2),pp.37-45 (Co-authored)
3.	2020/05	Papers	Higher Blood Uric Acid in Female Humans and Mice as a Protective Factor Against Pathophysiological Decline of Lung Function. Antioxidants 9 (5),pp.387 (Co-authored)
4.	2020/04	Papers	Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases. Biochemical and Biophysical Research Communications 524 (2),pp.332-339 (Co-authored)
5.	2020/01	Papers	Azithromycin inhibits constitutive airway epithelial sodium channel activation in vitro and modulates downstream pathogenesis in vivo. Biological and Pharmaceutical Bulletin 43 (4),pp.725-730 (Co-authored)
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Academic conference presentation
1.	2024/10	HDAC3 inhibition enhances IL-37-dependent anti-Inflammatory pathway via SIGIRR/IL-18Rα up-regulation (18th Young Investigator Symposium on Clinical Pharmaceutical Science)
2.	2017/02	Poly(I:C)-dependent anti-inflammatory IL-37b-SIGIRR negative feedback loop is defective in cystic fibrosis airway epithelial cells (15th Cytokines & Inflammation)
3.	2013/09	Lipopolysaccharide decreases SIGIRR expression by suppressing Sp1 via TLR4-p38 MAP kinase pathway in monocytes and neutrophils (Cytokines 2013)
4.	2013/09	Increased IL-17C production by TLR3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells (Cytokines 2013)

Academic background
1.	2000/04～2004/03	Faculty of Pharmaceutical Science Kumamoto University Graduated
2.	2004/04～2006/03	Master Graduate School, Division of Pharmaceutical Sciences Kumamoto University Finished
3.	2006/04～2009/03	Doctorial Graduate School, Division of Pharmaceutical Sciences Kumamoto University Finished

Business career
1.	2008/04/01 ～ 2010/03/31	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2.	2010/04/01 ～ 2018/03/31	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

researchmap Researcher code
B000346847

Research topic, funded research, and department laboratory expense
1.	2019/04 ～ 2021/03	Elucidation of the regulation mechanism of cystic fibrosis-specific splice variant expression and development of novel therapeutic strategies Grant-in-Aid for Scientific Research (C)
2.	2016/04 ～ 2019/03	Therapeutic application to cystic fibrosis based on IL-37 and stabilized cell surface expression of SIGIRR Grant-in-Aid for Scientific Research（C）
3.	2014/04 ～ 2016/03	Molecular basis of SIGIRR expression and regulatory function in Cystic Fibrosis and its therapeutic approach Grant-in-Aid for Young Scientists（B）

E-Mail Address

Present specialized field
Biological pharmacy

Department laboratory expense researcher number
70510692